癌組織の形態情報ならびに分子発現情報と臨床情報をリンクした多次元的な解析を行うことで、各臓器がんに特徴的な病態に関わる分子機構、がん間質相互作用に代表される様な複雑な生体内での細胞・分子ネットワークの解明を目指しています。

　具体的には、１）個々の臓器癌の特徴的な病理像（多段階発癌、浸潤・転移）の詳細な臨床病理解析、２）それら癌組織の網羅的遺伝子・タンパク発現解析と、in situ発現解析、３）Tissueマイクロアレイ、デジタルスライド、蛍光定量デジタルスライド技術の応用による形態分子情報の定量解析、４）高度免疫不全マウス同所移植によるin vivo機能解析モデルの確立と応用を行い、癌の新規診断マーカーあるいは治療標的の候補分子を効率よく同定、解析しています。中でも、難治癌の代表である肝癌・膵癌・肺癌・卵巣癌等を主な対象とし、これまでに、早期肝細胞癌診断マーカー（HSP70, CAP2）・早期肺腺癌診断マーカー(MRP3)の開発、膵癌神経浸潤モデルの確立と制御分子(CD74, SNCG)の同定、EMTの分子病理研究、肝細胞癌・基底細胞癌で過剰発現するWnt・Hh標的分子(GPR49/LGR5)の同定などを行ってきました。

　代表的な研究の一つとして、肝細胞癌の多段階発癌モデルをご紹介します。

 

肝細胞癌の多段階発癌モデル

HCC, hepatocellular carcinoma, 肝細胞癌;
CLD, chronic liver disease, 慢性肝疾患; RN, regenerative nodule, 再生結節;
DN, dysplastic nodule, 異型結節; N/N, nodule-in-nodule, 結節内結節

　肝細胞癌の大半は、慢性障害肝（ウイルス性肝炎、アルコール性・非アルコール性肝障害等）を背景として発生します。癌になる前の段階（異型結節）や既存の構造を置き換えるように増生する癌（早期肝細胞癌）から結節内結節（早期肝細胞癌から進行肝細胞癌に移行つつある状態）を経て進行肝細胞癌となっていくことが知られています。こうしたモデルを多段階発癌モデルといいます。肝臓は癌の領域が比較的わかりやすいため、癌の評価が他臓器よりも容易です。こうした特徴を活かし、次のような研究を行っています。
（Jpn J Clin Oncol 40(9):891-896, 2010より一部改変して転載）

 

 

　多段階発現モデルを用いると様々なことが分かってきます。写真左は結節内結節の肝細胞癌の顕微鏡写真で、非癌部・早期肝細胞癌・進行肝細胞癌が含まれています（それぞれ組織像が異なっています）。各段階の組織を採取して網羅的遺伝子解析を行いました。

　例えば、非癌部と癌部（特に早期肝細胞癌）を比較したところ、HSP70・CAP2・Bmi-1等の遺伝子が癌部で高く発現していることがわかりました。研究を進めたところ、これらの遺伝子に対応した分子が癌を診断するのに役立つことが分かったため、診断マーカーや悪性度診断に応用されています．

　また、早期肝細胞癌と進行肝細胞癌の部分を比較したところ、p53やCK19等の遺伝子が進行肝細胞癌で高く発現することがあることがわかりました。このような遺伝子の発現が癌の悪性度（浸潤性が強い、転移しやすい、再発しやすい等）にどのように関わっているのか、そのメカニズムを現在研究中です。
（Jpn J Clin Oncol 40(9):891-896, 2010より一部改変して転載）

 

 

　進行癌、早期癌、背景肝におけるH&E像および同部における各種マーカーの免疫染色所見です。慢性障害肝→早期肝細胞癌→進行肝細胞癌と見ていくと、免疫染色の染色結果が異なることが見て取れます。HSP70やCAP-2は早期肝細胞癌の段階から段階的に発現の増加が認められますが、Bmi-1は早期肝細胞癌の段階で特に発現が高い傾向があります。一方、p53やCK19については多段階発癌過程の後期に発現異常を認めることが多いです。
（Jpn J Clin Oncol 40(9):891-896, 2010より一部改変して転載）

 

研究成果

2021年

Okano N, Furuse J, Ueno M, Morizane C, Yamanaka T, Ojima H, Ozaka M, Sasaki M, Takahara N, Nakai Y, Kobayashi S, Morimoto M, Hosoi H, Maeno S, Nagashima F, Ikeda M, Okusaka T.
Multicenter Phase II Trial of Axitinib Monotherapy for Gemcitabine-Based Chemotherapy Refractory Advanced Biliary Tract Cancer (AX-BC Study).
Oncologist. 2021;26(2):97-e201.

Morisue R, Kojima M, Suzuki T, Nakatsura T, Ojima H, Watanabe R, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Ishii G, Gotohda N, Fujiwara T, Ochiai A. Sarcomatoid hepatocellular carcinoma is distinct from ordinary hepatocellular carcinoma:　Clinicopathologic, transcriptomic and immunologic analyses.
Int J Cancer. 2021;149(3):546-560.

Takemura Y, Ojima H, Oshima G, Shinoda M, Hasegawa Y, Kitago M, Yagi H, Abe Y, Hori S, Fujii-Nishimura Y, Kubota N, Masuda Y, Hibi T, Sakamoto M, Kitagawa Y. Gamma-synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma.
Cancer Med. 2021;10(16):5599-5613.

Rapid Progress in Immunotherapies for Multiple Myeloma: An Updated Comprehensive Review
Hiroko Nishida
Cancers (Basal). 2021; 13: 2712(1-31)

Immunovascular classification of HCC reflects reciprocal interaction between immune and angiogenic tumor microenvironments.
Kurebayashi Y, Matsuda K, Ueno A, Tsujikawa H, Yamazaki K, Masugi Y, Kwa WT, Effendi K, Hasegawa Y, Yagi H, Abe Y, Kitago M, Ojima H, Sakamoto M.
Hepatology. Online ahead of print. 2021年10月

Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and Collagen.
Ogawa Y, Masugi Y, Abe T, Yamazaki K, Ueno A, Fujii-Nishimura Y, Hori S, Yagi H, Abe Y, Kitago M, Sakamoto M.
Clin Cancer Res. 2021; 27: 107-119.

Indication for resection and possibility of observation for intraductal papillary mucinous neoplasm with high-risk stigmata.
Abe K, Kitago M, Masugi Y, Iwasaki E, Yagi H, Abe Y, Hasegawa Y, Fukuhara S, Hori S, Tanaka M, Nakano Y, Yokose T, Shimane G, Sakamoto M, Kitagawa Y.
Pancreatology. 2021; 21: 755-762.

Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.
Sano M, Takahashi R, Ijichi H, Ishigaki K, Yamada T, Miyabayashi K, Kimura G, Mizuno S, Kato H, Fujiwara H, Nakatsuka T, Tanaka Y, Kim J, Masugi Y, Morishita Y, Tanaka M, Ushiku T, Nakai Y, Tateishi K, Ishii Y, Isayama H, Moses HL, Koike K.
Gut. 2021; 70: 1713-1723.

Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma.
Ugai T, Zhao M, Shimizu T, Akimoto N, Shi S, Takashima Y, Zhong R, Lau MC, Haruki K, Arima K, Fujiyoshi K, Langworthy B, Masugi Y, da Silva A, Nosho K, Baba Y, Song M, Chan AT, Wang M, Meyerhardt JA, Giannakis M, Väyrynen JP, Nowak JA, Ogino S. OncoImmunol. 2021; 10: 1956173.

Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin.
Komine R, Kojima M, Ishi G, Kudo M, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Kobayashi T, Akimoto T, Murakami A, Sasaki M, Tanaka M, Matsuzaki A, Ohike N, Uchida K, Sugiyama T, Hirabayashi K, Tajiri T, Ishida K, Kai K, Omori Y, Notohara K, Yamaguchi H, Matsuda Y, Naito Y, Fukumura Y, Hamada Y, Mihara Y, Masugi Y, Gotohda N, Harada K, Fukushima N, Furukawa T.
Cancer Med. 2021; 10: 3499-3510.

Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease.
Asakura T, Kimizuka Y, Nishimura T, Suzuki S, Namkoong H, Masugi Y, Sato Y, Ishii M, Hasegawa N.
Respirology. 2021; 26: 112-119.

Tumor and Tumor-Associated Macrophage PD-L1 Expression is Associated with Adjuvant Chemotherapy Benefit in Lung Adenocarcinoma.
Gross DJ, Chintala NK, Vaghjiani RG, Grosser R, Tan KS, Li X, Choe J, Li Y, Aly RG, Emoto K, Zheng H, Dux J, Cheema W, Bott MJ, Travis WD, Isbell JM, Li BT, Jones DR, Adusumilli PS.
J Thorac Oncol 2021; 17: 89-102..

Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer.
Ishioka K, Yasuda H, Hamamoto J, Terai H, Emoto K, Kim TJ, Hirose S, Kamatani T, Mimaki S, Arai D, Ohgino K, Tani T, Masuzawa K, Manabe T, Shinozaki T, Mitsuishi A, Ebisudani T, Fukushima T, Ozaki M, Ikemura S, Kawada I, Naoki K, Nakamura M, Ohtsuka T, Asamura H, Tsuchihara K, Hayashi Y, Hegab AE, Kobayashi SS, Kohno T, Watanabe H, Ornitz DM, Betsuyaku T, Soejima K, Fukunaga K.
Cancer Res 2021; 81: 3916-3929

Lipofibroadenoma arising in hyperplastic thymic tissue: Possible perivascular origin of lipofibroadenoma.
Kurebayashi Y, Hayashi Y, Emoto K, Kaseda K, Asamura H, Mukai K, Sakamoto M. Pathol Int 2021;71: 275-277

Nontuberculous, Mycobacteriosis Bronchiectasis - Japan Research, Consortium. Genome-wide association study in patients with pulmonary Mycobacterium avium complex disease.
Namkoong H, Omae Y, Asakura T, Ishii M, Suzuki S, Morimoto K, Kawai Y, Emoto K, Oler AJ, Szymanski EP, Yoshida M, Matsuda S, Yagi K, Hase I, Nishimura T, Sasaki Y, Asami T, Shiomi T, Matsubara H, Shimada H, Hamamoto J, Jhun BW, Kim SY, Huh HJ, Won HH, Ato M, Kosaki K, Betsuyaku T, Fukunaga K, Kurashima A, Tettelin H, Yanai H, Mahasirimongkol S, Olivier KN, Hoshino Y, Koh WJ, Holland SM, Tokunaga K, Hasegawa N.
Eur Respir J 2021: 58.

Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer.
Patel AS, Yoo S, Kong R, Sato T, Sinha A, Karam S, Bao L, Fridrikh M, Emoto K, Nudelman G, Powell CA, Beasley MB, Zhu J, Watanabe H.
Sci Adv 2021: 7.

PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment.
Takehara T, Wakamatsu E, Machiyama H, Nishi W, Emoto K, Azuma M, Soejima K, Fukunaga K, Yokosuka T.
Commun Biol 2021; 4: 581.

Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus
Hisato Iriki, Hayato Takahashi, Naoko Wada, Hisashi Nomura, Miho Mukai, Aki Kamata, Hiromi Ito, Jun Yamagami, Takeshi Matsui, Yutaka Kurebayashi, Setsuko Mise-Omata, Hiroshi Nishimasu, Osamu Nureki, Akihiko Yoshimura, Shohei Hori, Masayuki Amagai
Proceedings of the National Academy of Sciences　2021; 118: e2026763118

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin
H. Takahashi, H. Nomura, H. Iriki, A. Kubo, K. Isami, Y. Mikami, M. Mukai, T. Sasaki, J. Yamagami, J. Kudoh, H. Ito, A. Kamata, Y. Kurebayashi, H. Yoshida, A. Yoshimura, H. W. Sun, M. Suematsu, J. J. O’Shea, Y. Kanno, M. Amagai
Science Immunology 2021: 6; eabb6444

Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis
Rei Morikawa, Nobuhiro Nakamoto, Takeru Amiya, Po-sung Chu, Yuzo Koda, Toshiaki Teratani, Takahiro Suzuki, Yutaka Kurebayashi, Akihisa Ueno, Nobuhito Taniki, Kentaro Miyamoto, Akihiro Yamaguchi, Shunsuke Shiba, Tadashi Katayama, Kosuke Yoshida, Yoshiaki Takada, Rino Ishihara, Hirotoshi Ebinuma, Michiie Sakamoto, Takanori Kanai
Journal of Hepatology 2021: 74; 511-521

A case of central nervous system lesion pathologically characterized by angiocentric, T-cell-rich lymphoid cell infiltrates: a case report and literature review.
Imai R, Tsujikawa H, Fukumura M, Sasaki A, Tsuda N, Kameyama K, Yoshida K, Sasaki H.
Brain Tumor Pathol. 2021 Jul;38(3):263-270.

CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells.
Koda Y, Teratani T, Chu PS, Hagihara Y, Mikami Y, Harada Y, Tsujikawa H, Miyamoto K, Suzuki T, Taniki N, Sujino T, Sakamoto M, Kanai T, Nakamoto N.
Nat Commun. 2021 Jul 22;12(1):4474.

尾島英知、田中伸哉　（編集）　
病理と臨床39巻9号2021年 9月発行　文光堂

日本肝臓学会NASH診断WG病理協議会　『NASH・NAFLDの診療ガイド〈2021〉』　
日本肝臓学会　2021年3月発刊　文光堂

尾島英知, 坂元亨宇　
【肝内胆管癌診療の最前線～ガイドラインReview～】『肝門部胆管癌と肝内胆管癌の肝門部浸潤を病理学的区別する意義』　
胆と膵42巻9号 Page797-800(2021.09)

尾島英知　
【病理医が知っておくべき法令や指針】『経験談　証拠保全を受けた病理解剖症例の経験』　病理と臨床39巻9号 Page911-913(2021.09)

尾島英知　
『大学内ネットワークを用いた病理解剖見学システムの構築』　
病理と臨床39巻8号 Page842-845(2021.08)

尾島英知
『【肝内胆管癌の診断と治療】WHO分類第5版の改訂ポイント』
消化器・肝臓内科 9巻4号 Page412-416, 2021年4月

久保田直人, 尾島英知, 坂元亨宇　
『【肝・胆道系症候群(第3版)-その他の肝・胆道系疾患を含めて-肝臓編(下)】肝腫瘍　肝細胞腺腫』
日本臨床別冊肝・胆道系症候群II Page136-141, 2021年2月

2020年

Inter-muscle differences in modulation of motor evoked potentials and posterior root-muscle reflexes evoked from lower-limb muscles during agonist and antagonist muscle contractions.
Saito A, Nakagawa K, Masugi Y, Nakazawa K
Experimental brain research 2020年11月

First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques.
Kisu I, Kato Y, Masugi Y, Ishigaki H, Yamada Y, Matsubara K, Obara H, Emoto K, Matoba Y, Adachi M, Banno K, Saiki Y, Sasamura T, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T
Journal of clinical medicine 9 （ 11 ） 2020年11月

Surgery for colloid carcinoma of the pancreas with portal vein tumor thrombus: a case report.
Udagawa D, Shimazu M, Sakuragawa T, Maruyama S, Uchi Y, Miura E, Masugi Y, Sakamoto M
Surgical case reports 6 （ 1 ） 252 2020年10月

Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques.Kisu I, Banno K, Obara H, Kato Y, Yamada Y, Matsubara K, Matoba Y, Adachi M, Emoto K, Masugi Y, Saiki Y, Ishigaki H, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Nakagawa K, Shiina T, Aoki D
The journal of obstetrics and gynaecology research 46 （ 11 ） 2251 - 2260 2020年09月

Telomerase reverse transcriptase (TERT) promoter mutation correlated with intratumoral heterogeneity in hepatocellular carcinoma
Kwa W.T., Effendi K., Yamazaki K., Kubota N., Hatano M., Ueno A., Masugi Y., Sakamoto M.
Pathology International 70 （ 9 ） 624 - 632 2020年09月

O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer.
Yokose T, Kabe Y, Matsuda A, Kitago M, Matsuda S, Hirai M, Nakagawa T, Masugi Y, Hishiki T, Nakamura Y, Shinoda M, Yagi H, Abe Y, Oshima G, Hori S, Nakano Y, Honda K, Kashiro A, Morizane C, Nara S, Kikuchi S, Shibahara T, Itonaga M, Ono M, Minegishi N, Koshiba S, Yamamoto M, Kuno A, Handa H, Sakamoto M, Suematsu M, Kitagawa Y
Cancers 12 （ 9 ） 1 - 17 2020年08月

Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques.
Kisu I, Emoto K, Masugi Y, Yamada Y, Matsubara K, Obara H, Matoba Y, Banno K, Kato Y, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Murase M, Nakagawa T, Tsuchiya H, Ishigaki H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T
Scientific reports 10 （ 1 ） 13910 2020年08月

Urgent distal pancreatectomy for intraperitoneal hemorrhage due to the spontaneous rupture of a pancreatic metastatic tumor from synovial sarcoma: a case report.
Yokose T, Kitago M, Oshima G, Abe K, Masugi Y, Miura E, Shinoda M, Yagi H, Abe Y, Hori S, Matsusaka Y, Endo Y, Toyama K, Okuda S, Kitagawa Y
BMC surgery 20 （ 1 ） 175 2020年08月

Insulin-Like Growth Factor-1 Receptor Expression and Disease Recurrence and Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma.
Du C, da Silva A, Morales-Oyarvide V, Dias Costa A, Kozak MM, Dunne RF, Rubinson DA, Perez K, Masugi Y, Hamada T, Brais LK, Yuan C, Babic A, Ducar MD, Thorner AR, Aguirre A, Kulke MH, Ng K, Clancy TE, Findeis-Hosey JJ, Chang DT, Hornick JL, Fuchs CS, Ogino S, Koong AC, Hezel AF, Wolpin BM, Nowak JA
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29 （ 8 ） 1586 - 1595 2020年08月

A case of pancreatic hamartoma with characteristic radiological findings: radiological-pathological correlation
Toyama K., Matsusaka Y., Okuda S., Miura E., Kubota N., Masugi Y., Kitago M., Hori S., Yokose T., Shinoda M., Sakamoto M., Jinzaki M.
Abdominal Radiology 45 （ 7 ） 2244 - 2248 2020年07月

Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer
Yokose T., Kitago M., Matsuda S., Sasaki Y., Masugi Y., Nakamura Y., Shinoda M., Yagi H., Abe Y., Oshima G., Hori S., Yusuke F., Nakano Y., Endo Y., Abe K., Tokino T., Kitagawa Y.
Cancer Science 111 （ 6 ） 2174 - 2182 2020年06月

Usefulness of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography for predicting the prognosis and treatment response of neoadjuvant therapy for pancreatic ductal adenocarcinoma
Yokose T., Kitago M., Matsusaka Y., Masugi Y., Shinoda M., Yagi H., Abe Y., Oshima G., Hori S., Endo Y., Toyama K., Iwabuchi Y., Takemura R., Ishii R., Nakahara T., Okuda S., Jinzaki M., Kitagawa Y.
Cancer Medicine （Cancer Medicine) 9 （ 12 ） 4059 - 4068 2020年06月

Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes
Adachi M., Masugi Y., Yamazaki K., Emoto K., Kobayashi Y., Tominaga E., Banno K., Aoki D., Sakamoto M.
Japanese Journal of Clinical Oncology 50 （ 6 ） 643 - 652 2020年05月

Association of autophagy status with amount of Fusobacterium nucleatum in colorectal cancer
Haruki K., Kosumi K., Hamada T., Twombly T.S., Väyrynen J.P., Kim S.A., Masugi Y., Qian Z.R., Mima K., Baba Y., da Silva A., Borowsky J., Arima K., Fujiyoshi K., Lau M.C., Li P., Guo C., Chen Y., Song M., Nowak J.A., Nishihara R., Yanaga K., Zhang X., Wu K., Bullman S., Garrett W.S., Huttenhower C., Meyerhardt J.A., Giannakis M., Chan A.T., Fuchs C.S., Ogino S.
Journal of Pathology 250 （ 4 ） 397 - 408 2020年04月

Clinicopathological features of hepatocellular carcinoma with fatty change: Tumors with macrovesicular steatosis have better prognosis and aberrant expression patterns of perilipin and adipophilin
Kubota N., Ojima H., Hatano M., Yamazaki K., Masugi Y., Tsujikawa H., Fujii-Nishimura Y., Ueno A., Kurebayashi Y., Shinoda M., Kitago M., Abe Y., Kitagawa Y., Sakamoto M
Pathology International （Pathology International) 70 （ 4 ） 199 - 209 2020年04月
Discovery of Pancreatic Ductal Adenocarcinoma-Related Aberrant Glycosylations: A Multilateral Approach of Lectin Microarray-Based Tissue Glycomic Profiling With Public Transcriptomic Datasets
Wagatsuma T., Nagai-Okatani C., Matsuda A., Masugi Y., Imaoka M., Yamazaki K., Sakamoto M., Kuno A.
Frontiers in Oncology 10 338 2020年03月

Precision pathology analysis of the development and progression of hepatocellular carcinoma: Implication for precision diagnosis of hepatocellular carcinoma
Ueno A., Masugi Y., Yamazaki K., Kurebayashi Y., Tsujikawa H., Effendi K., Ojima H., Sakamoto M.
Pathology International （Pathology International) 70 （ 3 ） 140 - 154 2020年03月

Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease
Asakura T., Kimizuka Y., Nishimura T., Suzuki S., Namkoong H., Masugi Y., Sato Y., Ishii M., Hasegawa N.
Respirology （Respirology) 26 （ 1 ） 112 - 119 2020年
A case of intrahepatic cholangiocellular carcinoma due to thorotrast deposition, well-controlled by radiofrequency ablation therapy
Taniki N., Nakamoto N., Yoshida A., Chu P.S., Ikura A., Yamataka K., Morikawa R., Shiba S., Yamaguchi A., Usui S., Ojiro K., Ebinuma H., Saito H., Kubota N., Masugi Y., Sakamto M., Kanai T.
Acta Hepatologica Japonica 61 （ 5 ） 262 - 269 2020年

Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism
Sano M., Takahashi R., Ijichi H., Ishigaki K., Yamada T., Miyabayashi K., Kimura G., Mizuno S., Kato H., Fujiwara H., Nakatsuka T., Tanaka Y., Kim J., Masugi Y., Morishita Y., Tanaka M., Ushiku T., Nakai Y., Tateishi K., Ishii Y., Isayama H., Moses H.L., Koike K
Gut （Gut) 2020年

Decreased αGlcNAc glycosylation in biliary tract cancer progression from BilIN to invasive adenocarcinoma
Okumura M., Yamanoi K., Uehara K., Nakayama J.
CANCER SCIENCE 2020年10月

Diffuse MIST1 expression and decreased αGlcNAc glycosylation on MUC6 are distinct hallmark for gastric neoplasms exhibiting oxyntic gland differentiation
Yamada S., Yamanoi K., Sato Y., Nakayama J
HISTOPATHOLOGY 77 （ 3 ） 413 2020年09月

Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy
Hayashi K., Hishikawa A., Hashiguchi A., Azegami T., Yoshimoto N., Nakamichi R., Tokuyama H., Itoh H.
Scientific Reports （Scientific Reports) 10 （ 1 ） 2020年12月

Evaluation of Gleason Grade Group 5 in a Contemporary Prostate Cancer Grading System and Literature Review
Kamitani R., Matsumoto K., Kosaka T., Takeda T., Hashiguchi A., Tanaka N., Morita S., Mizuno R., Shinojima T., Asanuma H., Oya M
Clinical Genitourinary Cancer 19 （ 1 ） 69 - 75.e5 2020年

The Newly Described Filigree Pattern Is an Expansion of the Micropapillary Adenocarcinoma Concept Rather Than a Proposed New Subtype
Emoto K., Tan K.S., Rekhtman N., Adusumilli P.S., Travis W.D.
Journal of Thoracic Oncology 15 ( 7 ) e121 - e124 2020年07月

Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis
Morikawa R., Nakamoto N., Amiya T., Chu P.s., Koda Y., Teratani T., Suzuki T., Kurebayashi Y., Ueno A., Taniki N., Miyamoto K., Yamaguchi A., Shiba S., Katayama T., Yoshida K., Takada Y., Ishihara R., Ebinuma H., Sakamoto M., Kanai T
Journal of Hepatology （Journal of Hepatology) 2020年

Imiquimod-induced dermatitis impairs thymic tolerance of autoreactive CD4+ T cells to desmoglein 3
Iriki H., Mukai M., Ito H., Kurebayashi Y., Amagai ,Takahashi H
Journal of Dermatological Science 100 （ 3 ） 166 - 174 2020年

IL-6 and G-CSF production resulting from lung cancer in an HIV patient
Kawakami N., Namkoong H., Masaki K., Kurebayashi Y., Shimoda M., Kotani H., Fujiwara H., Hasegawa N.
IDCases 19 2020年

Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen
Ogawa Y., Masugi Y., Abe T., Yamazaki K., Ueno A., Fujii-Nishimura Y., Hori S., Yagi H., Abe Y., Kitago M., Sakamoto M.
Clinical Cancer Research 27 （ 1 ） 107 - 119 2020年10月

Incidentally detected microcystic serous cystadenoma of the pancreas with splenic invasion: a case report and literature review
Yagi, F., Akita, H., Ueno, A., Takano, K., Masugi, Y., Sakamoto, M., Kitago, M., Shinoda, M., Kitagawa, Y., Toyama, K., Matsusaka, Y., Yashiro, H., Okuda, S. and Jinzaki, M
BJR Case Rep 6 （ 2 ）2020年09月

Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recoveryIshii M., Itano O., Shinoda M., Kitago M., Abe Y., Hibi T., Yagi H., Takeuchi A., Tsujikawa H., Abe T., Kitagawa Y.
World Journal of Gastroenterology 26 （ 8 ） 725 - 739 2020年02月

2019年

Effectiveness of color correction on the quantitative analysis of histopathological images acquired by different whole-slide scanners
Aziz M., Nakamura T., Yamaguchi M., Kiyuna T., Yamashita Y., Abe T., Hashiguchi A., Sakamoto M.
Artificial Life and Robotics （Artificial Life and Robotics) 24 （ 1 ） 28 - 37 2019年03月

Steatotic and nonsteatotic scirrhous hepatocellular carcinomas reveal distinct clinicopathological features
Hatano M., Ojima H., Masugi Y., Tsujikawa H., Hiraoka N., Kanai Y., Shimada K., Shinoda M., Sakamoto M.
Human Pathology （Human Pathology) 86 222 - 232 2019年04月

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract CarcinomaSaito Y., Muramatsu T., Kanai Y., Ojima H., Sukeda A., Hiraoka N., Arai E., Sugiyama Y., Matsuzaki J., Uchida R., Yoshikawa N., Furukawa R., Saito H
Cell Reports 2019年

Monoclonal antibody therapies in multiple myeloma: a challenge to develop novel targets.
Hiroko Nishida, Taketo Yamada
Journal of Oncology. 2019; 6084012 (1 - 10 )

Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome
Haruta M., Arai Y., Okita H., Tanaka Y., Takimoto T., Sugino R., Yamada Y., Kamijo T., Oue T., Fukuzawa M., Koshinaga T., Kaneko Y
Neoplasia (United States) 21 （ 1 ） 117 - 131 2019年01月

Characterization of spatial distribution of tumor-infiltrating CD8 + T cells refines their prognostic utility for pancreatic cancer survival
Masugi Y., Abe T., Ueno A., Fujii-Nishimura Y., Ojima H., Endo Y., Fujita Y., Kitago M., Shinoda M., Kitagawa Y., Sakamoto M.
Modern Pathology 32 （ 10 ） 1495 - 1507 2019年

Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis
Fujita Y., Matsuda S., Sasaki Y., Masugi Y., Kitago M., Yagi H., Abe Y., Shinoda M., Tokino T., Sakamoto M., Kitagawa Y.
Cancer Science 111 （ 2 ） 739 - 748 2019年12月

Activation of ERK Is Associated with Hepatocellular Carcinoma with Aggressive Phenotypes.
Minagawa T, Yamazaki K, Masugi Y, Tsujikawa H, Ojima H, Hibi T, Abe Y, Yagi H, Kitago M, Shinoda M, Itano O, Kitagawa Y, Sakamoto M
Hepatology research : 50 （ 3 ） 353 - 364 2019年11月

Clinical and Endoscopic Characteristics of Pyogenic Granuloma in the Small Intestine: A Case Series with Literature Review.
Hayashi Y, Hosoe N, Takabayashi K, Kamiya KJL, Mutaguchi M, Miyanaga R, Hirata K, Fukuhara S, Mikami Y, Sujino T, Masugi Y, Naganuma M, Ogata H, Kanai T.
Internal medicine 59 （ 4 ） 501 - 505 2019年10月

Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques.
Kisu I, Ishigaki H, Emoto K, Kato Y, Yamada Y, Matsubara K, Obara H, Masugi Y, Matoba Y, Adachi M, Banno K, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Tsuchiya H, Sasamura T, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T
Journal of clinical medicine 8 （ 10 ） 2019年10月

Efficacy and safety of preoperative 5-fluorouracil, cisplatin, and mitomycin C in combination with radiotherapy in patients with resectable and borderline resectable pancreatic cancer: A long-term follow-up study
Endo Y., Kitago M., Aiura K., Shinoda M., Yagi H., Abe Y., Oshima G., Hori S., Nakano Y., Itano O., Fukada J., Masugi Y., Kitagawa Y.
World Journal of Surgical Oncology 17 （ 1 ） 145 2019年08月

Macrophage migration inhibitory factor-CD74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells.
Imaoka M, Tanese K, Masugi Y, Hayashi M, Sakamoto MCancer science 110 （ 7 ） 2273 - 2283 2019年05月

Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells
Yang W., Liu L., Keum N., Qian Z., Nowak J., Hamada T., Song M., Cao Y., Nosho K., Smith-Warner S., Zhang S., Masugi Y., Ng K., Kosumi K., Ma Y., Garrett W., Wang M., Nan H., Giannakis M., Meyerhardt J., Chan A., Fuchs C., Nishihara R., Wu K., Giovannucci E., Ogino S., Zhang X.
Cancer Prevention Research 12 （ 5 ） 283 - 293 2019年05月

Smoking and risk of colorectal cancer sub-classified by tumor-infiltrating T cells
Hamada T., Nowak J., Masugi Y., Drew D., Song M., Cao Y., Kosumi K., Mima K., Twombly T., Liu L., Shi Y., Da Silva A., Gu M., Li W., Nosho K., Keum N., Giannakis M., Meyerhardt J., Wu K., Wang M., Chan A., Giovannucci E., Fuchs C., Nishihara R., Zhang X., Ogino S.
Journal of the National Cancer Institute 111 （ 1 ） 42 - 51 2019年01月

Non-invasive liver fibrosis assessment correlates with collagen and elastic fiber quantity in patients with hepatitis C virus infection
Yasui Y., Abe T., Kurosaki M., Matsunaga K., Higuchi M., Tamaki N., Watakabe K., Okada M., Wang W., Shimizu T., Takaura K., Masugi Y., Nakanishi H., Tsuchiya K., Takahashi Y., Itakura J., Sakurai U., Hashiguchi A., Sakamoto M., Izumi N
Hepatology Research 49 （ 1 ） 33 - 41 2019年01月

αGlcNAc and its catalyst α4GnT are diagnostic and prognostic markers in uterine cervical tumor, gastric type
Ida K., Yamanoi K., Asaka S., Takeuchi H., Miyamoto T., Shiozawa T., Nakayama J.
Scientific Reports 9 （ 1 ） 13043 2019年09月

Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda
Kawakubo M., Komura H., Goso Y., Okumura M., Sato Y., Fujii C., Miyashita M., Arisaka N., Harumiya S., Yamanoi K., Yamada S., Kakuta S., Kawashima H., Fukuda M.N., Fukuda M., Nakayama J.
Journal of Histochemistry and Cytochemistry 67 （ 10 ） 759 - 770 2019年06月

Annexin A1 expression is correlated with malignant potential of renal cell carcinoma
Yamanoi M., Yamanoi K., Fujii C., Fukuda M., Nakayama J
International Journal of Urology 26 （ 2 ） 284 - 290 2019年02月

Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring
Awazu M., Abe T., Hashiguchi A., Hida M.PLoS ONE （PLoS ONE) 14 （ 9 ） 2019年09月

Acute Interstitial Nephritis With Karyomegalic Epithelial Cells After Nivolumab Treatment—Two Case Reports
Ryuzaki M., Tokuyama H., Uchiyama K., Nakaya H., Hasegawa K., Miyashita K., Konishi K., Hashiguchi A., Wakino S., Itoh H
Clinical Medicine Insights: Case Reports 12 2019年06月

A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity
Okonogi H., Kawamura T., Joh K., Koike K., Miyazaki Y., Ogura M., Tsuboi N., Hirano K., Matsushima M., Yokoo T., Horikoshi S., Suzuki Y., Yasuda T., Shirai S., Shibata T., Hattori M., Akioka Y., Katafuchi R., Hashiguchi A., Hisano S., Shimizu A., Kimura K., Maruyama S., Matsuo S., Tomino Y.
Clinical and Experimental Nephrology 23 （ 1 ） 16 - 25 2019年01月

Prediction of extraprostatic extension by MRI tumor contact length: difference between anterior and posterior prostate cancer
Matsumoto K., Akita H., Narita K., Hashiguchi A., Takamatsu K., Takeda T., Kosaka T., Mizuno R., Kikuchi E., Oya M., Jinzaki M.Prostate Cancer and Prostatic Diseases （Prostate Cancer and Prostatic Diseases) 22 （ 4 ） 539 - 545 2019年

Predicting spread through air spaces (STAS) preoperatively: Can imaging help?Johnston R., Emoto K., Dux J., Travis W., Adusumilli P.
Journal of Thoracic Disease 11 ( Suppl 15 ) S1938 - S1941 2019年

Contiguous Metastasis of Pulmonary Adenocarcinoma to Meningioma
Nakaya M., Ichimura S., Kurebayashi Y., Mochizuki Y., Fukaya R., Fukuchi M., Fujii K.
Journal of Neurological Surgery, Part A: Central European Neurosurgery 80 （ 2 ） 127 - 130 2019年

Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35
Koda Y., Nakamoto N., Chu P., Ugamura A., Mikami Y., Teratani T., Tsujikawa H., Shiba S., Taniki N., Sujino T., Miyamoto K., Suzuki T., Yamaguchi A., Morikawa R., Sato K., Sakamoto M., Yoshimoto T., Kanai T
Journal of Clinical Investigation 129 （ 8 ） 3201 - 3213 2019年08月

Diffuse and canalicular patterns of glypican-3 expression reflect malignancy of hepatocellular carcinoma
Kawaida M., Yamazaki K., Tsujikawa H., Fukuma M., Abe Y., Kitago M., Shinoda M., Kitagawa Y., Sakamoto M.
Pathology International 69 （ 3 ） 125 - 134 2019年03月

FDG-PET/CTの集積で診断され術中の局所診断に苦慮した非機能性膵神経内分泌腫瘍(PNET)の1切除例　病変の術中検出限界、ピットフォールについて
竹村 裕介, 北郷 実, 板野 理, 篠田 昌宏, 八木 洋, 阿部 雄太, 大島 剛, 堀 周太郎, 藤田 優裕, 益田 悠貴, 久保田 直人, 辻川 華子, 川井田 みほ, 北川 雄光膵臓 （日本膵臓学会) 34 （ 1 ） 22 - 29 2019年02月

Clinical value of 3D SPECT/CT imaging for assessing jaw bone invasion in oral cancer patients
Miyashita H., Nakahara T., Asoda S., Kameyama K., Kawaida M., Enomoto R., Shiba H., Jinzaki M., Kawana H., Nakagawa T
Journal of Cranio-Maxillofacial Surgery 47 （ 7 ） 1139 - 1146 2019年07月

Living donor liver re-transplantation for recurrent hepatoblastoma in the liver graft following complete eradication of peritoneal metastases under indocyanine green fluorescence imaging
Takahashi N., Yamada Y., Hoshino K., Kawaida M., Mori T., Abe K., Fujimura T., Matsubara K., Hibi T., Shinoda M., Obara H., Isshiki K., Shima H., Shimada H., Kameyama K., Fuchimoto Y., Kitagawa Y., Kuroda T
Cancers 11 （ 5 ） 2019年05月

Successful resection of pancreatic metastasis from oesophageal squamous cell carcinoma: a case report and review of the literature
Koizumi W., Kitago M., Shinoda M., Yagi H., Abe Y., Oshima G., Hori S., Inomata K., Kawakubo H., Kawaida M., Kitagawa Y.
BMC Cancer 19 （ 1 ） 2019年04月

Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases
Matoba Y., Banno K., Kisu I., Kobayashi Y., Tsuji K., Nagai S., Yamagami W., Nakamura M., Tominaga E., Kawaida M., Aoki D.
Journal of Minimally Invasive Gynecology 2019年

Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literatureYokose T., Obara H., Shinoda M., Nakano Y., Kitago M., Yagi H., Abe Y., Yamada Y., Matsubara K., Oshima G., Hori S., Ibuki S., Higashi H., Masuda Y., Hayashi M., Mori T., Kawaida M., Fujimura T., Hoshino K., Kameyama K., Kuroda T., Kitagawa Y.
World Journal of Gastroenterology 25 （ 15 ） 1899 - 1906 2019年

2018年

Accuracy of non-invasive scoring systems for diagnosing non-alcoholic steatohepatitis-related fibrosis: Multicenter validation study
Itoh Y., Seko Y., Shima T., Nakajima T., Mizuno K., Kawamura Y., Akuta N., Ito K., Kawanaka M., Hiramatsu A., Sakamoto M., Harada K., Goto Y., Nakayama T., Kumada H., Okanoue T.
Hepatology Research 48 （ 13 ） 1099 - 1107 2018年12月

Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components
Fujita Y., Kitago M., Abe T., Itano O., Shinoda M., Abe Y., Yagi H., Hibi T., Ishii M., Nakano Y., Okuma K., Hashimoto M., Takeuchi A., Masugi Y., Jinzaki M., Sakamoto M., Kitagawa Y.
Pancreas 47 （ 10 ） 1277 - 1282 2018年11月

CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma
Nishida H., Hayashi M., Morimoto C., Sakamoto M., Yamada T.
Blood Cancer Journal 8 （ 11 ） 2018年11月

Immunohistochemical visualization of the signature of activated Hedgehog signaling pathway in cutaneous epithelial tumors
Tanese K., Emoto K., Kubota N., Fukuma M., Sakamoto M
.Journal of Dermatology 45 （ 10 ） 1181 - 1186 2018年10月

Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification
Kurebayashi Y., Ojima H., Tsujikawa H., Kubota N., Maehara J., Abe Y., Kitago M., Shinoda M., Kitagawa Y., Sakamoto M.
Hepatology 68 （ 3 ） 1025 - 1041 2018年09月

cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation
Brunt E., Aishima S., Clavien P., Fowler K., Goodman Z., Gores G., Gouw A., Kagen A., Klimstra D., Komuta M., Kondo F., Miksad R., Nakano M., Nakanuma Y., Ng I., Paradis V., Nyun Park Y., Quaglia A., Roncalli M., Roskams T., Sakamoto M., Saxena R., Sempoux C., Sirlin C., Stueck A., Thung S., Tsui W., Wang X., Wee A., Yano H., Yeh M., Zen Y., Zucman-Rossi J., Theise N.
Hepatology 68 （ 1 ） 113 - 126 2018年07月

Bone-Targeted Agents in Multiple Myeloma
Hiroko Nishida
Hematology Reports. 2018; 10 (12-16).

Novel method for DNA methylation analysis using high-performance liquid chromatography and its clinical application
Yotani T., Yamada Y., Arai E., Tian Y., Gotoh M., Komiyama M., Fujimoto H., Sakamoto M., Kanai Y.
Cancer Science 109 （ 5 ） 1690 - 1700 2018年05月

Concurrent presentation of an intraductal tubulopapillary neoplasm and intraductal papillary mucinous neoplasm in the branch duct of the pancreas, with a superior mesenteric artery aneurysm: A case reportInomata K., Kitago M., Obara H., Fujii-Nishimura Y., Shinoda M., Yagi H., Abe Y., Hibi T., Matsubara K., Oshima G., Sekimoto Y., Inoue M., Itano O., Sakamoto M., Kitagawa Y.
World Journal of Surgical Oncology 16 （ 1 ） 2018年04月

Mesenchymal–epithelial transition of pancreatic cancer cells at perineural invasion sites is induced by Schwann cells
Fujii-Nishimura Y., Yamazaki K., Masugi Y., Douguchi J., Kurebayashi Y., Kubota N., Ojima H., Kitago M., Shinoda M., Hashiguchi A., Sakamoto M
Pathology International 68 （ 4 ） 214 - 223 2018年04月

Impact of resection and ablation for single hypovascular hepatocellular carcinoma ≤2 cm analysed with propensity score weighting
Takayasu K., Arii S., Sakamoto M., Matsuyama Y., Kudo M., Kaneko S., Nakashima O., Kadoya M., Izumi N., Takayama T., Ku Y., Kumada T., Kubo S., Kokudo T., Hagiwara Y., Kokudo N.
Liver International 38 （ 3 ） 484 - 493 2018年03月

The challenges and promises of quanifying liver fibrosis and steatosis evaluation of liver fibrosis: From the viewpoint of pathology
Hatano M., Abe T., Hashiguchi A., Sakamoto M.Acta Hepatologica Japonica 59 ( 8 ) 415 - 420 2018年

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system
Saito Y., Nakaoka T., Muramatsu T., Ojima H., Sukeda A., Sugiyama Y., Uchida R., Furukawa R., Kitahara A., Sato T., Kanai Y., Saito H.
Scientific Reports 8 （ 1 ） 2018年12月

Epigenome mapping of human normal purified hepatocytes: Personal epigenome variation and genome-epigenome correlation
Arai E., Miura F., Totoki Y., Yamashita S., Tian Y., Gotoh M., Ojima H., Nakagawa H., Takahashi Y., Nakamura H., Hama N., Kato M., Kimura H., Suzuki Y., Ito T., Shibata T., Kanai Y.
Epigenomics 10 （ 7 ） 955 - 979 2018年07月

PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay
Sakamoto Y., Yamagishi S., Tanizawa Y., Tajimi M., Okusaka T., Ojima H.
Japanese Journal of Clinical Oncology 48 （ 4 ） 396 - 399 2018年04月

The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses
Kanai Y., Nishihara H., Miyagi Y., Tsuruyama T., Taguchi K., Katoh H., Takeuchi T., Gotoh M., Kuramoto J., Arai E., Ojima H., Shibuya A., Yoshida T., Akahane T., Kasajima R., Morita K., Inazawa J., Sasaki T., Fukayama M., Oda Y
.Pathology International 68 （ 2 ） 63 - 90 2018年02月

The potentiality of laparoscopic partial liver excisional biopsy using analysis of the liver surface based on preoperative 3D simulation imaging: A case report
Ei S., Itano O., Yoshida H., Ojima H., Shimoda M., Uchida H., Maeda S., Kumamoto Y., Aiko S.
International Journal of Surgery Case Reports 45 33 - 37 2018年

A curative treatment strategy using tumor debulking surgery combined with immune checkpoint inhibitors for advanced pediatric solid tumors: An in vivo study using a murine model of osteosarcoma
Shimizu T., Fuchimoto Y., Okita H., Fukuda K., Kitagawa Y., Ueno S., Kuroda T.
Journal of Pediatric Surgery 53 （ 12 ） 2460 - 2464 2018年12月

Preoperative diagnosis of clear cell sarcoma of the kidney by detection of BCOR internal tandem duplication in circulating tumor DNA
Ueno-Yokohata H., Okita H., Nakasato K., Hishiki T., Shirai R., Tsujimoto S., Osumi T., Yoshimura S., Yamada Y., Shioda Y., Kiyotani C., Terashima K., Miyazaki O., Matsumoto K., Kiyokawa N., Yoshioka T., Kato M.
Genes Chromosomes and Cancer 57 （ 10 ） 525 - 529 2018年10月

Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A report from the Japan Children's Cancer Group (JCCG)
Koshinaga T., Takimoto T., Oue T., Okita H., Tanaka Y., Nozaki M., Tsuchiya K., Inoue E., Haruta M., Kaneko Y., Fukuzawa M.
Pediatric Blood and Cancer 65 （ 7 ） e27056 2018年04月

Tumour CD274 (PD-L1) expression and T cells in colorectal cancer
Masugi, Y., Nishihara, R., Yang, J., Mima, K., da Silva, A., Shi, Y., Inamura, K., Cao, Y., Song, M., Nowak, J. A., Liao, X., Nosho, K., Chan, A. T., Giannakis, M., Bass, A. J., Hodi, F. S., Freeman, G. J., Rodig, S., Fuchs, C. S., Qian, Z. R. and Ogino, S.
Gut 2016年05月

Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status
Hamada, T., Cao, Y., Qian, Z. R., Masugi, Y., Nowak, J. A., Yang, J., Song, M., Mima, K., Kosumi, K., Liu, L., Shi, Y., da Silva, A., Gu, M., Li, W., Keum, N., Zhang, X., Wu, K., Meyerhardt, J. A., Giovannucci, E. L., Giannakis, M., Rodig, S. J., Freeman, G. J., Nevo, D., Wang, M., Chan, A. T., Fuchs, C. S., Nishihara, R. and Ogino, S.
J Clin Oncol 35 （ 16 ） 1836 - 1844 2017年06月

Indication for resection and possibility of observation for intraductal papillary mucinous neoplasm with high-risk stigmata.
Abe K, Kitago M, Masugi Y, Iwasaki E, Yagi H, Abe Y, Hasegawa Y, Fukuhara S, Hori S, Tanaka M, Nakano Y, Yokose T, Shimane G, Sakamoto M, Kitagawa Y
Pancreatology 2021年02月

Peritoneal dissemination of pancreatic cancer caused by endoscopic ultrasound-guided fine needle aspiration: A case report and literature review.
Kojima H, Kitago M, Iwasaki E, Masugi Y, Matsusaka Y, Yagi H, Abe Y, Hasegawa Y, Hori S, Tanaka M, Nakano Y, Takemura Y, Fukuhara S, Ohara Y, Sakamoto M, Okuda S, Kitagawa Y
World journal of gastroenterology 27 （ 3 ） 294 - 304 2021年01月

The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome
Kosumi K., Hamada T., Koh H., Borowsky J., Bullman S., Twombly T., Nevo D., Masugi Y., Liu L., da Silva A., Chen Y., Du C., Gu M., Li C., Li W., Liu H., Shi Y., Mima K., Song M., Nosho K., Nowak J., Nishihara R., Baba H., Zhang X., Wu K., Wang M., Huttenhower C., Garrett W., Meyerson M., Lennerz J., Giannakis M., Chan A., Meyerhardt J., Fuchs C., Ogino S
American Journal of Pathology 188 （ 12 ） 2839 - 2852 2018年12月

Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components
Fujita Y., Kitago M., Abe T., Itano O., Shinoda M., Abe Y., Yagi H., Hibi T., Ishii M., Nakano Y., Okuma K., Hashimoto M., Takeuchi A., Masugi Y., Jinzaki M., Sakamoto M., Kitagawa Y.
Pancreas 47 （ 10 ） 1277 - 1282 2018年11月

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status
Hamada T., Zhang X., Mima K., Bullman S., Sukawa Y., Nowak J., Kosumi K., Masugi Y., Twombly T., Cao Y., Song M., Liu L., da Silva A., Shi Y., Gu M., Li W., Koh H., Nosho K., Inamura K., Keum N., Wu K., Meyerhardt J., Kostic A., Huttenhower C., Garrett W., Meyerson M., Giovannucci E., Chan A., Fuchs C., Nishihara R., Giannakis M., Ogino S
Cancer immunology research 6 （ 11 ） 1327 - 1336 2018年11月

Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour
Hamada T., Liu L., Nowak J., Mima K., Cao Y., Ng K., Twombly T., Song M., Jung S., Dou R., Masugi Y., Kosumi K., Shi Y., da Silva A., Gu M., Li W., Keum N., Wu K., Nosho K., Inamura K., Meyerhardt J., Nevo D., Wang M., Giannakis M., Chan A., Giovannucci E., Fuchs C., Nishihara R., Zhang X., Ogino S.
European Journal of Cancer 103 98 - 107 2018年11月

Liver Fibrosis Markers Improve Prediction of Outcome in Non-Acetaminophen-Associated Acute Liver Failure.
Ugamura A, Chu PS, Nakamoto N, Taniki N, Ojiro K, Hibi T, Shinoda M, Obara H, Masugi Y, Yamaguchi A, Shiba S, Morikawa R, Usui S, Ebinuma H, Kitagawa Y, Saito H, Kanai T
Hepatology communications 2 （ 11 ） 1331 - 1343 2018年11月

Characterization of the Neuroendocrine Tumor Immune MicroenvironmentDa Silva A., Bowden M., Zhang S., Masugi Y., Thorner A., Herbert Z., Zhou C., Brais L., Chan J., Hodi F., Rodig S., Ogino S., Kulke M.
Pancreas 47 （ 9 ） 1123 - 1129 2018年10月

Physical Activity and Colorectal Cancer Prognosis According to Tumor-Infiltrating T Cells.
Koh H, Hamada T, Song M, Liu L, Cao Y, Nowak JA, da Silva A, Twombly T, Morikawa T, Kim SA, Masugi Y, Kosumi K, Shi Y, Gu M, Li W, Du C, Chen Y, Li W, Liu H, Li C, Wu K, Nosho K, Inamura K, Hanyuda A, Zhang X, Giannakis M, Chan AT, Fuchs CS, Nishihara R, Meyerhardt JA, Ogino SJNCI cancer spectrum 2 （ 4 ） pky058 2018年10月

Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis
Ma S., Ogino S., Parsana P., Nishihara R., Qian Z., Shen J., Mima K., Masugi Y., Cao Y., Nowak J., Shima K., Hoshida Y., Giovannucci E., Gala M., Chan A., Fuchs C., Parmigiani G., Huttenhower C., Waldron L.
Genome Biology 19 （ 1 ） 142 2018年09月

Quantitative assessment of liver fibrosis reveals a nonlinear association with fibrosis stage in nonalcoholic fatty liver disease.
Masugi Y, Abe T, Tsujikawa H, Effendi K, Hashiguchi A, Abe M, Imai Y, Hino K, Hige S, Kawanaka M, Yamada G, Kage M, Korenaga M, Hiasa Y, Mizokami M, Sakamoto M
Hepatology communications 2 （ 1 ） 58 - 68 2018年01月

TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas
Hamada T., Soong T., Masugi Y., Kosumi K., Nowak J., da Silva A., Mu X., Twombly T., Koh H., Yang J., Song M., Liu L., Gu M., Shi Y., Nosho K., Morikawa T., Inamura K., Shukla S., Wu C., Garraway L., Zhang X., Wu K., Meyerhardt J., Chan A., Glickman J., Rodig S., Freeman G., Fuchs C., Nishihara R., Giannakis M., Ogino S.
OncoImmunology （OncoImmunology) 7 （ 7 ） e1442999 2018年

Gastric gland mucin-specific O-glycan expression decreases as tumor cells progress from lobular endocervical gland hyperplasia to cervical mucinous carcinoma, gastric typeYamanoi K., Ishii K., Tsukamoto M., Asaka S., Nakayama J.
Virchows Archiv （Virchows Archiv) 473 （ 3 ） 305 - 311 2018年09月

Leucine-rich repeat-containing G-protein-coupled receptor 5 expression and clinicopathological features of colorectal neuroendocrine neoplasms
Nakajima T, Uehara T, Kobayashi Y., Kinugawa Y., Yamanoi K., Maruyama Y., Suga T., Ota H.
Pathology International 68 （ 8 ） 467 - 472 2018年08月

S状結腸癌に同時発生した直腸子宮内膜症癌化の1例
富岡寛行、西田祥二、吉安俊介、宮本昌武、松本涼子、山ノ井一裕
手術 （金原出版(株)) 72 （ 8 ） 1305 - 1309 2018年07月

リンチ症候群のスクリーニング
山ノ井 一裕
信州医学雑誌 （信州医学会) 66 （ 3 ） 221 - 223 2018年

【病理診断の新潮流】 発症機序を考慮した糸球体疾患の分類
橋口 明典
腎臓内科・泌尿器科 7 （ 3 ） 201 - 205 2018年03月

Quantitative assessment of liver fibrosis reveals a nonlinear association with fibrosis stage in nonalcoholic fatty liver disease.
Yohei Masugi, Tokiya Abe, Hanako Tsujikawa, Kathryn Effendi, Akinori Hashiguchi, Masanori Abe, Yasuharu Imai, Keisuke Hino, Shuhei Hige, Miwa Kawanaka, Gotaro Yamada, Masayoshi Kage, Masaaki Korenaga, Yoichi Hiasa, Masashi Mizokami, Michiie Sakamoto
Hepatology communications 2 （ 1 ） 58 - 68 2018年01月

CPC解説　脾破裂をきたした芽球性形質細胞様樹状細胞腫瘍の1剖検例
久保田 直人, 下田 将之, 江本 桂, 荒川 和清, 中間 楽平, 横倉 英人, 増田 義洋, 末盛 友浩, 眞杉 洋平
病理と臨床 ((株)文光堂) 36 ( 4 ) 385 - 390 2018年04月

Tracing the origin, tracking the evolution, and the treatment of the future
Emoto K., Vaghjiani R., Adusumilli P.
Journal of Thoracic and Cardiovascular Surgery 155 ( 3 ) 1203 - 1204 2018年03月

A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus
Inomata K., Tajima K., Yagi H., Higashi H., Shimoda H., Matsubara K., Hibi T., Abe Y., Tsujikawa H., Kitago M., Shinoda M., Obara H., Itano O., Soto-Gutierrez A., Kitagawa Y
Scientific Reports 8 （ 1 ） 14987 2018年12月

A gastric follicular lymphoma presenting as a submucosal tumor with a diagnosis determined by endoscopic resection
Fujimoto A., Akimoto T., Nakayama A., Mikami S., Tsujikawa H., Kameyama K., Okamoto S., Maehata T., Ochiai Y., Goto O., Kato M., Sasaki M., Uraoka T., Yahagi N.Internal Medicine （Internal Medicine) 57 （ 13 ） 1849 - 1853 2018年

Metastasectomy of Hepatoblastoma Utilizing a Novel Overlay Fluorescence Imaging System
Yamada Y., Hoshino K., Mori T., Kawaida M., Abe K., Takahashi N., Fujimura T., Kameyama K., Kuroda T.
Journal of Laparoendoscopic and Advanced Surgical Techniques 28 （ 9 ） 1152 - 1155 2018年09月

Successful living donor liver retransplantation for graft failure within 7 days due to acute de novo donor-specific anti-human leukocyte antigen antibody-mediated rejection
Yamada Y., Hoshino K., Mori T., Kawaida M., Abe K., Ishihama H., Shimizu T., Takahashi N., Matsubara K., Hibi T., Abe Y., Yagi H., Shimojima N., Shinoda M., Kitago M., Obara H., Fuchimoto Y., Kameyama K., Kitagawa Y., Kuroda T.
Hepatology Research 48 （ 3 ） E360 - E366 2018年02月

Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
Ishigaki S., Masaoka T., Kameyama H., Kawaida M., Kameyama K., Mori T., Kanai T.
Internal medicine 57 （ 22 ） 3249 - 3254 2018年